A new study published in the Journal of Functional Biomaterials suggests that the routine addition of collagen membranes over titanium meshes or titanium-reinforced membranes may not be essential in guided bone regeneration (GBR) procedures for vertical ridge augmentation (VRA). The researchers conducted a systematic review and meta-analysis of available animal studies and found no significant benefit in bone gain or complication rates when a collagen membrane was layered on top of titanium meshes. This challenges a widely practiced clinical step and raises questions about its necessity, especially considering cost, surgical complexity, and material handling. While titanium meshes already provide structural stability and space maintenance during bone regeneration, the added membrane may not further enhance clinical outcomes in all cases. The authors emphasize, however, that these findings are based on preclinical data, and well-designed human randomized controlled trials are needed to confirm the results before any changes to current protocols are recommended. Still, the study opens a conversation around simplifying GBR protocols and reducing biomaterial use where it may not offer added value. Until human evidence emerges, clinicians are advised to weigh the risks and benefits on a case-by-case basis.